Abstract Background Aberrant inflammatory responses drive the initiation and progression of various diseases. and hyperactivation of NLRP3 inflammasome is a key pathogenetic mechanism. Pharmacological inhibitors of NLRP3 represent a potential therapy for treating these diseases but are not yet clinically available. The natural product butein has excellent anti-inflammatory activity. https://www.roneverhart.com/Small-Sebenza-31-Titanium-Carbon-Fiber-Handle-Insingo-CPM-MagnaCut-Blade-Blue-Single-Lug/